Replication ebola

The fusion of the virion envelope with the plasma membrane of the host cell has the effect of releasing the nucleocapsid into the cytoplasm of the target cell. The RNA-dependent RNA polymerase L strips partially genomic RNA and transcribed into messenger RNA positive polarity which are then translated into proteins. RNA polymerase L of Ebola virus binds to a single promoter located at the 5 'end of the viral genome. Gene expression then proceeds sequentially, with increasing probability to pause as the polymerase moves along the strand genomic RNA transcription, the first gene from the promoter is thus further expressed that the latter gene to the 3 'end. The order of genes on the viral genome and provides a simple but effective way to regulate their transcription: the nucleoprotein NP, encoded by the first gene is produced in greater quantities than the L polymerase, encoded by the last gene. The concentration of the nucleoprotein in the cytosol of the host determines when the latch L polymerase transcription - production of messenger RNA from the genomic RNA - to viral replication - producing RNA antigenomes positive polarity with a full original genomic RNA replication. These are their antigenomes transcribed viral RNA genomes of negative polarity which interact with the lap previously translated from RNA viral structural proteins. Viral particles self-assemble from protein and genetic material newly produced near the cell membrane. They bud from the cell in a way overlapping viral envelope of the plasma membrane, which are inserted glycoproteins GP, releasing new virions ready to infect other cellules31.