Ebola pathogenicity

The incubation period ranges from 2 to 21 days, usually from April to September jours45. One week after the onset of symptoms, virions invade the blood and cells of the infected person. The most relevant cells are monocytes, macrophages and dendritic cells. The progression of the disease usually reaches the functioning of vital organs, especially the kidneys and liver. This causes severe internal bleeding. Death occurs shortly after by organ failure and cardiopulmonary shock.

Ebola saturates all organs and tissues except bone and muscle motors. This first form of small blood clots diffuse throughout the vessels from disseminated intravascular coagulation whose mechanism is not clair46. The clots then stick to the walls of blood vessels to form a "tiling". Over the infection progresses, the clots are many, blocking capillaries. Eventually, they become so numerous that they block the blood arrival in the various organs of the body. Some parts of the brain, liver, kidney, lung, testes, skin and bowel then necrotic because they suffer from a lack of oxygenated blood.

One of the peculiarities of the Ebola virus is the brutality with which he attacks the connective tissues. It also causes red spots called petechiae resulting from subcutaneous bleeding. It affects the collagen of the skin structure. Sub-layers of the skin die and liquefy which causes red and white bubbles called maculopapular. At this point, simply touching the skin tears as she is softened.

The virus causes severe inflammatory reaction, but some viral proteins appear to inhibit interféron47.